In vitro cultures of cisplatin-treated GCs to which metformin was added have displayed a significant reduction in the expression of senescence markers (p21, p16, and NF-B) and senescence-associated secretory phenotype (SASP) markers, IL-6 and IL-1, and in a number of senescence-associated beta-galactosidase (SA-gal)-staining cells, and ultimately, improved functional and structural changes occurred in cisplatin-induced POF mice (Lin et al., 2022)
Astrocytes contribute to the ECM, as the main source of fibronectin after demyelination, which can inhibit OL differentiation and remyelination 161
The handling editor YX declared a shared affiliation with the author ZZ at the time of review
The key takeaway is that the wrong amount of bac water, whether too much or too little, will compromise the integrity of your experiment
The most common side effect at high doses (above 1,500mg IV) is transient mild hypotension or sulfur-related gastrointestinal discomfort
Peptide vials intended for research should be kept in a cool, dry location, at temperatures of -20 C or lower
